PCSK9 and skeletal system disorder: For URTI and asthma, our study findings replicate nominally significant findings in a previous phenome scan of another functional variant in PCSK9 conducted within the UKB.24,27 In addition to these three respiratory disease outcomes, meta-analysis of our results with those from UKB strengthened the evidence for an association of PCSK9 genetic variants with mood disorders and with non-deforming dorsopathies (diseases of the spine).