CKB and coronary artery disorder: Mendelian randomization studies in Europeans have shown that a 1 SD reduction in LDL-C (equivalent to ∼1 mmol/L) leads to a reduction in risk of CHD of approximately 40%.47 This compares to a more modest association in CKB for a comparable outcome of around 25% per 1 SD lower LDL-C, although this is at least partly attributable to a smaller SD for LDL-C in CKB (0.69 mmol/L) than in European populations.