PTGS2 and brain infarction: Figure 8B showed that the transfection was clearly successful in rats. TTC staining revealed that sh-PTGS2 administration could significantly reduce the volume of cerebral infarction compared with the MCAO group of rats (Figure 8C, 8D). Moreover, the neurological deficit scores and edema volume of rats were remarkably decreased following silencing PTGS2 (Figure 8E, 8F). More importantly, sh-PTGS2 rescued the neuronal damage, Nissl bodies decreased and nuclear shrinkage induced by MCAO (Figure 8G, 8H).