This effect of T1D and OSM on HSC mobilopathy was found to be dependent on the adaptor protein SHC1, since targeted Shc1 deletion in hematopoietic cells in T1D mice partially corrected the HSC mobilopathy, reduced myelopoiesis, and restored the BM vascular architecture [116••]. This evidence concerns the gene SHC1 and type 1 diabetes mellitus.