This protein is encoded by the THBD gene and variants including A43T (Impaired binding of Complement factor H (CFH) and C3b) [15], P495S and P501L (Moderate reduction of thrombomodulin expression on the cell surface) [16] and D486Y (Less common in patients with venous thrombosis) [17] are identified. Here, THBD is linked to Venous thrombosis.