Schimke Immuno-Osseous Dysplasia (SIOD) is an autosomal recessive multi-system disorder, with the genetic cause of biallelic loss-of-function mutation in SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1) gene [8]. The gene discussed is SMARCAL1; the disease is Schimke immuno-osseous dysplasia.