Although the beginning of the N-terminus (TAU12) was generally the most available epitope for binding to human brain tissue, pS396 tau (E178) was the most abundant phospho-epitope detected in AD cases with and without concomitant aSyn pathology, closely followed by pS198 (EPR2400), pS199 (2H23L4) and pS422 (EPR2866). Here, MAPT is linked to Alzheimer disease.