MAPT and Alzheimer disease: Hyperphosphorylation of tau is seen as a driving factor in the pathogenesis of AD and tau pathology has been described to precede Aβ pathology in the brain for roughly a decade, based the current theory that hyperphosphorylation of tau results in its detachment from the microtubules, resulting in aggregation of tau and subsequent formation of neurofibrillary tangles (NFTs), neuronal loss and dysconnectivity [4, 43].