In the insoluble fraction, more pS396 tau was detected in the AD cases compared to all other groups (vs AD-LB, p = 0.01; vs PDD, p < 0.0001; vs controls, p < 0.0001) and more pS396 tau was detected in the insoluble fraction versus the soluble fraction, as highlighted by an interaction between values measured and type of fraction (p < 0.0001). The gene discussed is MAPT; the disease is Alzheimer disease.