This finding is consistent with previous studies where increased content of p62 was detected in intraneuronal protein aggregates in ALS with dementia patients [26], in oligodendroglial inclusions in the motor cortex of patients with ALS phenotypes caused by mutations in CHMP2B [27] and in other ALS cases [28]. The gene discussed is CHMP2B; the disease is amyotrophic lateral sclerosis.