Cytoplasmic aggregation of misfolded TAR DNA-binding protein-43 (TDP-43) occurs in 97% of cases of amyotrophic lateral sclerosis (ALS) and almost half of frontotemporal lobar degeneration (FTLD; Ling et al., 2013; Tan et al., 2017). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.