TARDBP and amyotrophic lateral sclerosis: While anti-pSer92 antibody did not react with the endogenous nuclear TDP-43 of cultured cells or human postmortem spinal motor neurons (Fig. 6, A–F; and Fig. 8, A and B), we found that 40% of skein-like inclusions, 75% of dot-like inclusions, and 85% of round inclusions in the sporadic ALS spinal motor neurons were positive for this antibody (Fig. 8, C–E).