The probability of uncontrolled acromegaly was also lower in those with IGF-1 levels 300–500 μg/L (ES = 0.37, 95% CI: 0.32–0.43), while it was significantly increased in those with IGF-1 values ≥700 μg/L at baseline (ES = 0.58, 95% CI: 0.53–0.64). Here, IGF1 is linked to acromegaly.