DDX1 and cancer: Previously published 50% inhibitory concentrations (IC50) for rapamycin from the Genomics of Drug Sensitivity in Cancer database (GDSC2; ref. 41) anticorrelated significantly with DDX1 copy-number in MYCN-amplified neuroblastoma cell lines (Fig. 6D, Pearson coefficient = −0.5043 in neuroblastoma cells, P = 0.0394), further corroborating the link between DDX1 coamplification and mTORC1 dependency.