CD40 and immunodeficiency disease: As expected, hyper-IgM immunodeficiency was found to likely affect naïve B cells through CD40 (receptor; PrEDiCT = 2.9, FDR = 0.06), and CD4αβ T cells through CD40LG (ligand; PrEDiCT = 3.7, FDR <0.001; Figure 4A).