Except for CASP7 and CYCS, K-M analysis showed that MPC1, COX6C and other genes had negative correlations with the overall survival of ESCC patients, while CYB5R3 had a positive correlation with them, suggesting the strong association of the overall expression of Hub OSRGs with ESCC’ prognosis. Here, CASP7 is linked to esophageal squamous cell carcinoma.