ENTPD1 and leukemia: Nonetheless, RUNX2-overexpression resulted in a significant reduction in the PD1+/CD39+ exhaustion phenotype of RUNX2-CAR8MD responding to WT leukemia and reduction in leukemia counts in marrow (Figure S9I) but no difference in other exhaustion phenotypes, CAR proportions or CAR counts (Figure 6K, S9K,L,O).