Nonetheless, RUNX2-overexpression resulted in a significant reduction in the PD1+/CD39+ exhaustion phenotype of RUNX2-CAR8MD responding to WT leukemia and reduction in leukemia counts in marrow (Figure S9I) but no difference in other exhaustion phenotypes, CAR proportions or CAR counts (Figure 6K, S9K,L,O). The gene discussed is PDCD1; the disease is leukemia.