Given the unique profile of chromatin accessibility for Runx-family binding motifs coupled with the pattern of Runx2 transcript expression which was high in PreCAR memory CD8+ T cells and then lost upon CAR transduction, we hypothesized that establishing RUNX2 expression in CAR8ND could enhance the existing memory-like profile of these T cells and boost T cell potency and anti-leukemia response. Here, CD8A is linked to leukemia.