Although CEACAM5 expression can also be found in gastrointestinal, genitourinary, breast and lung cancers, a recent unbiased surface profiling effort showed a strong enrichment of CEACAM5 expression in NEPC and subsequent in vivo models demonstrated activity of a CEACAM5 ADC in NEPC PDX models 26,30. This evidence concerns the gene CEACAM5 and lung carcinoma.