While these data present intriguing novel insights between the expression of TROP2, DLL3 and PSMA with common genomic alterations in CRPC, it is important to note that these associations are also tightly associated with tumor phenotype (i.e., AR amplification is seen in AR+/NE− tumors, whereas RB1 loss is enriched in NEPC). This evidence concerns the gene RB1 and neoplasm.