GBP1 and breast cancer: Previous research has identified GBP1 as a monomer initiating protein which acts as a carcinogen in the occurrence, development, invasion and metastasis of BC.8 Additionally, the risk of brain metastasis is increased through T lymphocyte induction of GBP1 overexpression within BC cells.9 However, the correlation between GBP1 and the risk of LNM in BC patients and the predictive value of GBP1 on prognosis still need further analysis.8,9