Evidence exists to propose the association of metabolic syndrome and periodontitis via altering periodontal microbiota, though scarcity prevails to confirm their positive association in both animal and human studies.36 The positive correlation between diabetes type-2 and periodontitis has been established so far in the literature through common mediators i.e. Matrix metalloproteinases-2-1 (MMP-2-14), IL-4, CRP, Interferon-gamma (IFN-γ), and Tissue inhibitors of metalloproteinases-2 (TIMP-2).37,38 (Table-I). This evidence concerns the gene TIMP2 and type 2 diabetes mellitus.