Several other anxiety-related conditions may potentiate periodontitis such as in earthquake victims a potential link was revealed between insomnia and periodontitis.34 A psychological disorder like Schizophrenia has also been announced as a risk factor for periodontal diseases through common intervening mediators namely IL-1β, IL-6, IL-9, TNF-α, TNF-β, PGE-2, and CRP.35 (Table-I). The gene discussed is TNF; the disease is periodontal disorder.