Administration of irisin led to improved mitochondrial function, increased expression of SOD and a decrease in the size of myocardial infarctions.23 These findings were in line with current study where significant decrease in oxidative stress markers and improvement in antioxidant enzymes level (SOD, CAT and GSH) was observed, thereby reinforcing protective nature of irisin in oxidative stress. Here, FNDC5 is linked to myocardial infarction.