Irisin, a peptide hormone, is secreted by skeletal muscle and adipose tissue in response to exercise due to proteolytic breakdown of fibronectin type III (FNDC5), a transmembrane protein.9 It has been postulated that irisin improves pro-oxidant-antioxidant balance by increasing mitochondrial enzymes expression.6 Recently, Irisin has gained great interest as potential target to combat diabetes, obesity and various metabolic disorders associated with these diseases. This evidence concerns the gene FNDC5 and metabolic disease.