Many adult cardiac processes revert to a fetal format during the development of heart failure.[14b] To further clarify the role of Cfp1 on cardiomyocyte maturation, we examined the cardiac morphology and function as well as the expression status of maturation related genes in ne‐cKO mice and found no obvious differences on cardiac structure and function, but marked abnormalities in the expression pattern of maturation related genes. This evidence concerns the gene CXXC1 and heart failure.