Therefore, we categorized and summarized the disease with respect to its multifaceted pathogenesis and clinical manifestations, with preventive tools including maternal health care to avoiding preterm birth, probiotic and breastfeeding for preterm infants (including donor breast milk) to avoid formula feeding, and targeting IL-10 and TLR4 and chondroitin sulfate to avoid infection and inflammation. This evidence concerns the gene IL10 and infection.