Decreased NUDT21 expression has been reported to promote cell proliferation in glioblastoma, bladder cancer, and hepatocellular carcinoma (Xiong et al. 2019; Masamha et al. 2014; Han and Kim 2014; Tan et al. 2018), and knockdown of NUDT21 also inhibits the proliferation and promotes apoptosis of human K562 leukemia cells through the ERK pathway (Zhang and Zhang 2018); NUDT21 also promotes the proliferation and metastasis in human gastric cancer through modulating SGPP2 (Zhu et al. 2021). Here, NUDT21 is linked to urinary bladder carcinoma.