ENPP2 and cancer: Notably, eosinophil ultrastructure differed noticeably between genotypes, with evidence of increased degranulation consistent with increased eosinophil activation in the ATX-inhibited context and evidence of ring-like bilobed nuclei in control tumors, as previously described for resolving or homeostatic eosinophils33 (Fig. 3a), suggesting regulation of both eosinophil abundance and phenotype by cancer cell-derived ATX.