ENPP2 and pancreatic neoplasm: Although mechanisms and consequences of eosinophil recruitment into pancreatic tumors have not been investigated, low circulating eosinophil frequencies and low eosinophil-to-lymphocyte ratios were found to be significant independent prognostic factors of poor outcomes among individuals with PDAC25, prompting us to further investigate the link between ATX–LPA signaling and eosinophils.