MAPT and amyloidosis: In line with plasma results, CSF p-tau217 showed higher Pearson correlation with amyloid-PET Centiloid (r = 0.66), tau-PET global-SUVR (r = 0.83), and MMSE (r = − 0.6, p < 0.001) in comparison with p-tau181 (amyloid: r = 0.58; tau: r = 0.79; cognition: r = − 0.46) and p-tau231 (amyloid: r = 0.57; tau: r = 0.76; cognition: r = − 0.37) (Fig. 1).