Additionally, when p-tau217 was compared to several other plasma biomarkers (such as p-tau231, p-tau181, amyloid-β 42/40, glial acidic fibrillary protein, and neurofilament light), it was found to be the only biomarker with longitudinal changes dependent on amyloid as well as associations with cognitive impairment and neurodegeneration [11]. This evidence concerns the gene NEFL and Cognitive impairment.