TP53 and cancer: Among the 89 identified missense driver genes in pan-cancer, 21 genes were detected in multiple cancer types, including known cancer genes such as TP53, KRAS, NRAS, and PIK3CA. Although most of these genes were identified in colorectal cancer, PIK3CA, TP53 and CTNNB1 were detected in other cancer types too (breast carcinoma, central nervous system glioma high grade, and gastric carcinoma).