In the pan-cancer analysis of all three alterations, several genes were identified as both non-missense and missense driver genes, including ATIC, MCRS1, TBL3, CACNA1A, TOP2A, and TP53. Moreover, NRAS, KRAS, and MAP2K1 were found to be amplification and missense driver genes. The gene discussed is KRAS; the disease is cancer.