PIK3CA and cancer: Four genes, namely KRAS (in breast carcinoma, non-small cell lung cancer (NSCLC), lymphoma multiple myeloma carcinoma, colorectal carcinoma, and leukemia), NRAS (in pancreatic carcinoma, bladder carcinoma, primitive neuro-ectodermal tumors (PNET)), PIK3CA (in breast carcinoma and ovarian carcinoma), and ARHGAP31 (in colorectal carcinoma and pancreatic carcinoma) were identified as missense driver genes in more than one cancer type.