In addition, unreported genes in IntOGen such as CANT1, IL20RA, BRX1, BUB1, ATIC, Twist2, and CSF2RB were identified by the NBDep method as putative missense mutational cancer genes but these genes were not detected by using APSiC on ATARiS and DEMETER2 gene-level scores. Here, PITX2 is linked to cancer.