Additionally, 16 identified non-missense mutational driver genes in the pan-cancer analyses were also detected as non-missense genes across cancer types, including CLSPN and PIK3C3 (NSCLC), PSMC1 and SETD5 (endometrial carcinoma), MGA (ovarian carcinoma), PTEN (CNS glioma), SP11 (leukemia), GNAI2 (lymphoma NH B-cell), and the eight genes in colorectal carcinoma. The gene discussed is PIK3C3; the disease is leukemia.