These include abnormal karyotype related traits (Down syndrome, Klinefelter syndrome), and several neural function-related traits (soluble tumor necrosis factor receptor 2 levels in plasma, neurodevelopmental presentations and congenital anomalies (ND/CAs), schizophrenia, myalgic encephalomyelitis/chronic fatigue syndrome, leukoaraiosis). The gene discussed is TNFRSF1B; the disease is Down syndrome.