NCOA6 and arthritic joint disease: Mechanistically, cytoplasmic NCOA6 was associated with the NACHT domain of NLRP3, promoting NLRP3 inflammasome activity in vitro, and in vivo experiments using mouse models of NLRP3-dependent inflammatory diseases, including folic acid (FA)-induced acute tubular necrosis and monosodium urate (MSU) crystal-induced arthritis, confirmed the in vitro results.