We identified 3889 DEGs (2601 upregulated and 1288 downregulated) in gout macrophages (Fig. 6A and Table S3) and found numerous shared genes between these DEGs and those in Ncoa6-KO macrophages (from Ncoa6fl/flLysMCRE mice) cultured with medium alone (no. of shared DEGs=178) or stimulated with LPS + MSU (no. of shared DEGs=200) (Fig. 6B). The gene discussed is NCOA6; the disease is gout.