NLRP3 and oculocutaneous albinism type 1: Therefore, we investigated the in vivo role of NCOA6 in FA-induced acute tubular necrosis (ATN), a mouse model of NLRP3-dependent inflammatory disease in which IL-1β is released in response to dying cells, subsequently causing tubular damage in the kidney, such as tubular necrosis, cast formation, and tubular dilatation [38].