When Ncoa6fl/flLysMCRE mice were subjected to MSU crystal-induced arthritis, they exhibited substantial attenuation of joint swelling compared to that of Ncoa6fl/fl mice as early as 3 h after MSU injection (Fig. 5G), and this response was more pronounced than that in Ncoa6-haploinsufficient mice (Fig. 5E, G). This evidence concerns the gene NCOA6 and arthritic joint disease.