Functional enrichment analysis of the 277 shared DEGs demonstrated that the response to type I IFN, regulation of the inflammatory response, innate immune response, leukocyte differentiation, and leukocyte migration were significantly enriched (Fig. 6C and Table S4), which supports the hypothesis that NCOA6 controls innate and inflammatory responses, including macrophage activation, migration, and differentiation, in gouty arthritis, an NLRP3-dependent inflammatory disorder in humans [41]. The gene discussed is NLRP3; the disease is gout.