For this purpose, we treated ZDHHC21-depleted DLBCL cells with orlistat, an inhibitor of FASN and found that ZDHHC21 depletion induced increase in proliferation ability, FASN enzyme activity and fatty acid level in DLBCL cells could be attenuated by treatment of orlistat (Fig. 4G–J). The gene discussed is FASN; the disease is diffuse large B-cell lymphoma.