To this end, we constructed stable DLBCL cell lines in which ZDHHC21-WT and ZDHHC21-mutant were overexpressed (Supplementary Fig. 3A, cysteine at 120 was mutated to alanine, and palmitoyltransferase activity was lost) in SU-DHL-6 cells, as well as in SU-DHL-2 and Toledo cell lines silenced for ZDHHC21 (Supplementary Fig. 3B). Here, ZDHHC21 is linked to diffuse large B-cell lymphoma.