To explore the circumstances of low ZDHHC21 expression in DLBCL, we firstly performed ZDHHC21 copy number variation analysis of 48 DLBCL cases in The Cancer Genome Atlas (TCGA) dataset and found that 3 out of 48 cases (6.25%) showed heterozygous deletion in ZDHHC21 locus. This evidence concerns the gene ZDHHC21 and diffuse large B-cell lymphoma.