Interestingly, ZDHHC21-mediated palmitoylation-dependent downregulation of FASN results in decreased fatty acid synthesis, which may in turn reduce palmitoylation of other FASN-dependent palmitoylated proteins because of decreased palmitate level; therefore, these results suggest that global protein palmitoylation regulation mediated by ZDHHC21 could exist in this context in DLBCL. Here, FASN is linked to diffuse large B-cell lymphoma.