To further investigate whether these transcription factors could regulate ZDHHC21 expression in DLBCL, we searched the promoter sequence of ZDHHC21 using JASPAR database and the results showed that there existed potential binding sites of NFKB1, NFKB2 and STAT3 (Supplementary Fig. 1C), and we further found that NFKB1 and NFKB2 expression significantly negatively correlated with ZDHHC21 expression in ABC subtype DLBCL patients but not in GCB subtype according to GSE53786 cohort. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.