For this purpose, we treated ZDHHC21-depleted DLBCL cells with orlistat, an inhibitor of FASN and found that ZDHHC21 depletion induced increase in proliferation ability, FASN enzyme activity and fatty acid level in DLBCL cells could be attenuated by treatment of orlistat (Fig. 4G–J). This evidence concerns the gene ZDHHC21 and diffuse large B-cell lymphoma.