ACE2 and COVID-19: Considering the situation in humans, clinical and histopathological studies of COVID-19 patients reported some dermatologic manifestations such as petechiae (a rash and haemorrhagic dot-like areas)70–73, and it has been suggested that angiotensin-converting enzyme 2 (ACE2)—used by SARS-CoV-2 to enter the host—can be highly expressed in keratinocytes74,75.