CD4 and neoplasm: To assess whether above-median T cell response was confounded by factors potentially associated with favorable prognosis30, we examined tumor stage and baseline immunologic parameters, including percentages of peripheral blood CD4+ and CD8+ T cells, peripheral blood neutrophil and total lymphocyte levels; tumor stage, baseline neutrophils and CD4+ and CD8+ T cells did not correlate with RFS (Extended Data Fig. 6).