Enrollment required (1) presence of a tumor mKRAS mutation (G12D or G12R) determined by whole-exome sequencing, (2) imaging studies negative for overt disease and (3) MRD state as adjudicated by detection of ctDNA positivity and/or elevated serum tumor antigen, carbohydrate antigen (CA) 19-9 or carcinoembryonic antigen (CEA) (Extended Data Fig. 1 and Extended Data Table 1). The gene discussed is CEACAM5; the disease is neoplasm.