MLKL and obesity due to melanocortin 4 receptor deficiency: In patients with MASLD and obesity, MLKL is also highly expressed and phosphorylated in multiple organs including liver and adipose tissue (Magusto et al, 2022; Wu et al, 2023) as well as multiple cell types, including liver parenchymal and non-parenchymal cells, such as hepatic stellate cells and immune cells (Guo et al, 2022; Wu et al, 2023).