While RIPKs and MLKL are critical players in the necroptotic pathway of cell death in pathological settings, emerging evidence suggests that each of the mediators of necroptosis also have extra-necroptotic functions that contribute to the regulation of metabolism, adding complexity to the understanding of necroptosis in the pathophysiology of metabolic diseases (Zhan et al, 2021). Here, MLKL is linked to metabolic disease.