Similar to what was observed in the LPS-induced ALI model, neutrophil-specific GSDME disruption also led to elevated production of anti-inflammatory cytokine IL-10 and attenuated production of proinflammatory IL-6 and IL-β (Fig. 8c), suppressed LDH secretion (Fig. 8d), as well as reduced total protein levels in BALF (Fig. 8e). This evidence concerns the gene IL6 and acute respiratory distress syndrome.