To confirm that the phenotype was mediated by GSDME disruption in neutrophils, we induced LPS pneumonia in Mrp8-cre(-)/Gsdmefl/fl (WT) and Mrp8-cre(+)/GsdmeΔ/Δ littermates and observed the inflammatory milieu (Fig. 6h). Here, GSDME is linked to susceptibility to pneumonia measurement.