This study was designed to demonstrate the effect and epigenetic mechanisms of high salt memory-induced hypertension and vasculopathy by observing the serum levels of endothelin-1 (ET-1), Nitric Oxide (NO), Tumor Necrosis Factor-α (TNF-α), and Interleukin-1β (IL-1β) and DNA methylation in heart tissue. This evidence concerns the gene TNF and Hypertension.