TFE3 and lymphangioleiomyomatosis: Indeed, MITF is considered a hallmark gene of lymphangioleiomyomatosis (LAM) and angiomyolipomas in TSC44,45, based on upregulation of genes that are known transcriptional targets of MITF/TFE3/TFEB/TFEC including MelanA and Cathepsin K46,47.