Furthermore, kidney-specific genetic inactivation of TFEB rescues renal disease in a mouse model of Birt-Hogg-Dubé (BHD) syndrome21, which is caused by loss-of-function mutations of the RagC/D GTP-ase activating protein folliculin (FLCN) and is characterized by skin tumors, lung cysts, and kidney cancer31. This evidence concerns the gene FLCN and kidney disorder.