IL18 and cancer: Indeed, we found that lower mRNA levels of CD86, HLA-A, B2M, CD80, and the proinflammatory cytokines IL6, IL-1β, and IL18 were induced by OXP/TNFα, suggesting that PANX1-mediated ATP release promoted dendritic cell maturation via P2RX7 (Fig. 5B and S6) and that the PANX1-P2RX7 axis, which promotes ATP release, regulates OXP-induced cancer immunogenicity.