PANX1 and neoplasm: ATP, which is a DAMP, is increasingly being recognized as an important factor that promotes the engulfment of dying cells [7–9], cross-presentation of tumor antigens to T cells and recruitment of tumor-infiltrating lymphocytes (TILs) [10–12] via several signaling pathways, including NF-kB signaling, RIPK-mediated NLRP inflammasome signaling and caspase-3 gated pannexin 1 (PANX1) channel-mediated signaling [7–9, 13–16].