IL18 and neoplasm: The mRNA levels of the proinflammatory factors Il-6, Il-1β, Il-18, GzmB and Ifnγ were elevated in the FOLFOX/BzATP group (Fig. 6A), suggesting that immunomodulatory ATP significantly enhanced dendritic cell maturation, promoting the release of proinflammatory cytokines and the recruitment of tumor-infiltrating CD8+ T cells.