To address this question, we used pre-infection samples from the 125 DENV-immune participants included in this study, collected prior to a subsequent DENV infection, and evaluated how the neutralization potency of antibodies from each participant varied across four assay conditions: partially mature DENV with Vero cells, partially mature DENV with Vero DC-SIGN cells, mature DENV with Vero cells, and mature DENV with Vero DC-SIGN cells (Fig. 2a). Here, CD209 is linked to infection.