miR-129-5p has been suggested to play roles in Alzheimer’s disease, potentially involving the regulation of autophagy [51], neuroinflammation [52, 54, 55], and neuronal cell death [53–55] through targeting amyloid precursor protein (APP) [51], high-mobility group box 1 (HMGB1) [55], and yes-associated protein 1 (YAP1) [53] genes. The gene discussed is YAP1; the disease is early-onset autosomal dominant Alzheimer disease.