Sixty-eight genes had significant MR associations with IOP but not POAG, such as HLA-B and SLC7A6, and 41 genes had significant MR associations with POAG but not IOP, such as CDKN2B-AS1, RERE, and YAP1, proposing high-confidence IOP-independent mechanisms (Supplementary Data 29 and Fig. 5). Here, SLC7A6 is linked to open-angle glaucoma.