We found 239 e/sGenes to have significant MR associations with both POAG and IOP, including TMCO1, GAS7, and LMX1B, which colocalized with the largest association signals for both POAG and IOP GWAS loci (Supplementary Figs. 5, 6, 9), and DGKG and NPC2, whose retina eQTLs colocalized with POAG and IOP. This evidence concerns the gene NPC2 and open-angle glaucoma.