For example, an increase in expression or alternative splicing of TMCO1, a gene that regulates the balance of calcium ions inside the endoplasmic reticulum, or a decrease in expression of LMX1B, LIM homeobox transcription factor 1 beta, that is essential for several developmental processes including the anterior segment of the eye68, were proposed to reduce POAG risk and IOP levels. This evidence concerns the gene TMCO1 and open-angle glaucoma.