For example, an increase in expression or alternative splicing of TMCO1, a gene that regulates the balance of calcium ions inside the endoplasmic reticulum, or a decrease in expression of LMX1B, LIM homeobox transcription factor 1 beta, that is essential for several developmental processes including the anterior segment of the eye68, were proposed to reduce POAG risk and IOP levels. Here, LMX1B is linked to open-angle glaucoma.