While there is direct evidence for BCL3 as a transactivator of cell cycle genes [102], the direct evidence for BCL3 mediated regulation of cell cycle genes in tumour cells has focussed on NF-kB mediated regulation of cyclinD1 in NSCLC, melanoma, hepatocellular carcinoma and osteocarcinoma cell lines [81, 99, 108]; CDK1 in glioblastoma [109]; p27 and c-Myc in triple negative breast cancer cells [40]; STAT3 mediated upregulation of cyclinD1 in glioma cells [15] and c-jun transcription factor (which regulates cyclinD1 transcription) in colorectal cell lines [56]. This evidence concerns the gene BCL3 and central nervous system cancer.