In colorectal carcinoma cells overexpression of BCL3 promoted both Ser473 and Thr308 phosphorylation of AKT and downstream target FOXO1/3a and GSK3β [12], while siRNA knockdown of BCL3 decreased phospho-AKT and downstream targets, in response to hypoxia. Here, AKT1 is linked to colorectal carcinoma.