A direct role for BCL3 in tumour cell migration/invasion has also been demonstrated in melanoma and gastric carcinoma cell lines [108, 113] whereby siRNA mediated knockdown of BCL3 expression resulted in a reduction in cell migration in in vitro (scratch) assays of cell motility, which in melanoma cells was accompanied by the loss of N-cadherin [108], attributed to the recruitment of BCL3 to an NF-kB binding site in the N-cadherin promoter. The gene discussed is CDH2; the disease is melanoma.