The Jamaican fruit bat kidney was found to be highly enriched for human kidney phenotypes, including glucose intolerance, metabolic alkalosis, abnormality of renin-angiotensin system, abnormal circulating renin, and hypokalemia (Supplementary Fig. 7f), fitting with our cell-type and scRNA-seq analyses that showed that the Jamaican fruit bat kidney resembles a diabetic kidney. Here, REN is linked to Hypokalemia.