SGK1 expression is widely detected in the brain, and it is increased in pathologic conditions such as Rett syndrome [186], Alzheimer disease (AD) [187, 188], multiple sclerosis [189], amyotrophic lateral sclerosis [190], and neuropathic pain [191], collectively suggesting that SGK1 plays pathogenic roles in neurodegenerative disorders. This evidence concerns the gene SGK1 and atypical Rett syndrome.