SGK1 expression is widely detected in the brain, and it is increased in pathologic conditions such as Rett syndrome [186], Alzheimer disease (AD) [187, 188], multiple sclerosis [189], amyotrophic lateral sclerosis [190], and neuropathic pain [191], collectively suggesting that SGK1 plays pathogenic roles in neurodegenerative disorders. Here, SGK1 is linked to early-onset autosomal dominant Alzheimer disease.