IFI16 and infection: Several reports assert that DNA of herpesviruses Kaposi’s sarcoma-associated herpesvirus (KSHV), Epstein-Barr virus (EBV), and herpes simplex virus 1 (HSV-1) during infection assembles an IFI16-containing oligomeric structure, leading to the production of active caspase-1 and IL-1β [51, 52].