STING and NLRP3 signaling pathways are activated in cirrhosis, and both knockdown of STING and STING inhibitor C-176 significantly inhibited NLRP3 expression and hepatocyte pyroptosis [87], suggesting that STING can induce hepatocyte pyroptosis through activation of the NLRP3 inflammasome. The gene discussed is STING1; the disease is Cirrhosis.