IL18 and neoplasm: STING enhanced IL-18 and IL-1β generation by macrophages by activation of NLRP3, and IL-18 and IL-1β induced 4-1BBL and 4-1BB expression in macrophages and NK cells, respectively, which facilitated macrophage STING signaling to improve anti-tumor function, thus suppressing colorectal cancer liver metastasis [205].