Similarly, knockdown of IFI204 by small interfering RNA significantly inhibited IFN-β release in response to bacterial infections such as Francisella novicida [44], Mycobacterium bovis [49], Staphylococcus aureus [50], demonstrating IFI204 is essential for host defense against intracellular and extracellular bacterial infection. This evidence concerns the gene IFNB1 and bacterial infectious disease.