NLRP3 and familial dilated cardiomyopathy: Also, in diabetic cardiomyopathy (DCM), the production of free fatty acids induced oxidative mitochondrial damage, activated the cGAS-STING and NLRP3 inflammasome signaling pathways, and ultimately promoted myocardial hypertrophy in DCM by promoting cardiomyocyte pyroptosis [139].