A strategy to investigate the indirect effect of tau pathology in astrocytes in AD on the desynchronization of the circadian clock and the contribution of tau astrogliopathy to sleep-wake disturbances in humans is to include in addition to a regular control group, a comparison group of tauopathy with prominent tau inclusions in astrocytes, such as PSP, CBD, or ARTAG. The gene discussed is MAPT; the disease is tauopathy.