Given the paucity of studies focusing on the relationship between microglia-circadian function and tau abnormalities, in a context of the increased recognition of microglia in modulating tauopathies, examining the microglial population and morphology in progressive tauopathies may be the next step in understanding the role of microglia in the progression of tauopathies and their impact on the master circadian rhythms mediated by the SCN. The gene discussed is MAPT; the disease is tauopathy.