MAPT and Alzheimer disease: For this review, searched the literature for the following terms: “Alzheimer’s disease”, “Progressive supranuclear palsy”, “Neurodegenerative disease”, “Sleep-wake disturbance”, “Pathology”, “Tau”, “Amyloid”, “Suprachiasmatic nucleus”, “Circadian rhythm”, “Circadian gene”, “Glia”, “Astrocyte”, “Microglia”, and “Inflammation”.