In addition, SIRT3 overexpression reduced the expression of NF-κB p65, suggesting that SIRT3 mediates the regulation of TGF-β1-induced inflammation mainly by regulating the expression of NF-κB p65 during renal fibrosis, data which are consistent with the results of other reports [44, 45]. This evidence concerns the gene SIRT3 and renal fibrosis.