When testing Halo-eYFP mice in the three-chamber apparatus, we found that VTA photoinhibition of LH-VGluT2 fibers was not reinforcing (Supplementary Fig. 4E), and it did not modify anxiety-like behaviors (Supplementary Fig. 7B, G, H), locomotion (Supplementary Fig. 7C, D) or freezing behavior (Supplementary Fig. 7E, F). Here, PLOD1 is linked to Anxiety.