BRCA1 and cancer: Regarding segregation analysis, both families were uninformative in this regard: family 1—the variant was from the father’s side without disease and not genotyped, and the carrier son age 49 does not have a disease; family 2—the variant was from the mother’s side and the carrier mother had a cancer type inconsistent with BRCA1-related disease, and no other cancers were reported in the other ungenotyped relatives.