In addition, some immune cells also play an important role in the development of NAFLD, such as CD8+T cells can secrete IFNγ and TNFɑ, and B cells are likely to accumulate in the liver leading to NASH through the secretion of IL-6 and TNFɑ [8].Therefore, the development of NAFLD is not simply the accumulation of lipids in the liver, but rather the joint action of internal and external factors (Fig. 1). Here, CD8A is linked to metabolic dysfunction-associated steatotic liver disease.