To evaluate whether attenuation of ASPP1 expression leads to functional consequences in acute leukemia, we utilized an in vitro FLT3 ITD PPP1R13B-knockdown cell model mimicking the clinical observation of an inferior outcome in this patient population (compare Fig. 3C/F): An RNA-interference (RNAi) approach was used to lentivirally silence PPP1R13B in the acute leukemia MOLM-14 cell line. This evidence concerns the gene FLT3 and acute leukemia.