Chemotherapy-resistant γδ T cells have been developed by introducing O6-alkylguanine DNA alkyl transferase, a DNA repair enzyme, into Vγ9Vδ2 T cells by lentiviral transduction to confer resistance to the chemotherapeutic drug temozolomide (TMZ) to treat glioblastoma. The gene discussed is LIG4; the disease is glioblastoma.