MARK2 knockdown has no impact on DAPK1-induced tau hyperphosphorylation [113], but the MARK2-induced tau phosphorylation and microtubule destabilization are potentiated by DAPK1 in neurons as DAPK1 overexpression enhances MARK2 activity in tauopathy [145]. Here, DAPK1 is linked to tauopathy.