DAPK1 and epilepsy: Interestingly, our research demonstrated that DAPK1 dysregulation in epilepsy is model-dependent, as convulsive dosing of pentylenetetrazol (PTZ) immediately activates the DAPK1 function in the mouse brain without upregulating its expression, while chronic exposure to PTZ at a low dose in the kindling model increased both the protein level and the activity of DAPK1 in the mouse brain [76].