We additionally revealed that pharmacological inhibition of DAPK1 activity by a selective DAPK1 inhibitor ((4Z)-4-(3-pyridylmethylene)-2-styryl-oxazol-5-one) significantly downregulates the amyloidogenic processing of APP and Aβ generation in different cell models, suggesting that DAPK1 is a promising target for early intervention of Aβ pathology in AD. Here, DAPK1 is linked to Alzheimer disease.