GRIN2B and ischemic stroke: Additionally, the upregulation of DAPK1 by Aβ oligomers leads to Ca2+ overload and excitotoxicity in the SH-SY5Y cell line via phosphorylation of the Ser1303 residue of the NMDAR GluN2B subunit, resembling the effect observed in an ischemic stroke mouse model [73, 111].