ATM and spontaneous abortion: Particularly, downregulated histamine degradation was associated with pregnancy complications, such as diabetes, miscarriage, and trophoblastic disorders [41]; Sirtuin deficiency impaired embryo invasion and decidualization [42]; ATM-deficient dams had lower implantation rates [43]; and excessive noradrenaline inhibited decidualization, embryo, and fetal development in mice [44].