PTEN and preeclampsia: Interestingly, several pathways predicted to be affected by gestational phase adenomyosis have been related to preeclampsia, including upregulated PPARα/RXRα activation, which negatively regulated trophoblast invasion and led to recurrent miscarriage [72]; excessive p53 signaling [73]; along with enhanced RHOGDI and PTEN, which also inhibited trophoblast invasion [74, 75].