From the top 20 upregulated DEGs (Fig. 2D), we note Cytochrome P450 Family 24 Subfamily A Member 1 (CYP24A1), C-X-C Motif Chemokine Ligand 14 (CXCL14), Cyclin Dependent Kinase Inhibitor 2 A (CDKN2A), Chloride Voltage-Gated Channel Ka (CLCNKA) and Platelet Activating Factor Receptor (PTAFR) (log2FC = 2.38, 1.55, 1.02, 1.01, and 0.80, respectively) due to their implication in spontaneous miscarriage, trophoblast outgrowth and invasion inhibition, and gestational diabetes mellitus. This evidence concerns the gene CDKN2A and gestational diabetes.