There was a significant association between high KIF18A H score expression and high tumor grade (p<0.001), advanced tumor stage grouping (p<0.009), nodal metastasis (p=0.001), advanced AJCC stage grouping (p<0.002), distant metastasis (p=0.015) (Fig. 2), associated high-grade DCIS (p<0.003), poor NPI (p<0.001), presence of lympho-vascular invasion (p<0.040), PR negative (p<0.015), Her2neu positive (p<0.001), high Ki67 proliferative index (p<0.033) (Fig. 3), and Her2neu enriched breast cancer (p<0.038) (Fig. 4). This evidence concerns the gene KIF18A and ductal breast carcinoma in situ.