High β-catenin H score was significantly in favor of advanced tumor stage grouping (p<0.002), nodal involvement (p<0.001), advanced AJCC stage grouping (p<0.001), presence of metastasis (p<0.025), high tumor grade (p<0.007), poor NPI group (p<0.001), associated high-grade DCIS (p<0.002), Her2neu positive (p<0.001), high Ki67 proliferative index (p<0.001), and Her2neu enriched breast cancer (p<0.001) (Figs. 6 and 7). The gene discussed is MKI67; the disease is breast cancer.