Furthermore, dendritic cells [9], mast cells [10], neutrophils [11], eosinophils [12] and T cell subsets (CD8 + T cells [13], Th17 [14], Th1 [15], Tregs [16], NKT [17]) also participate in high-fat diet induced obesity and related metabolic disorders. The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.