We compared the performance of two models; one including age, gender, ethnicity, BMI, WHR, AST:ALT, FIB-4 index, liver PDFF, liver iron and liver volume (the volume model); the other including age, gender, ethnicity, BMI, WHR, AST:ALT, FIB-4 index, liver PDFF, liver iron, liver volume and the principal component scores of the S2S distances (the S2S model), for the liver disease (N = 364) and T2D (N = 288) case-control cohorts. Here, GPT is linked to type 2 diabetes mellitus.